Novel approaches on prodrug based drug design
نویسندگان
چکیده
منابع مشابه
Prodrug Design vs. Drug Design
A drug is defined as a substance which is used in the cure, relief, diagnosis, treatment, or prevention of disease. The development of any potential drug commences with the study of the biochemistry and physiology behind a disease for which pharmaceutical intervention is feasible [1]. Prodrug is a term that was first introduced by Albert to signify a pharmacologically inactive chemical moiety t...
متن کاملProfessional rational drug and biological product design methods based on chemoinformatics as a novel science
Background: The use of new technologies in the field of drug discovery and development plays an important role in introducing new and effective drugs, optimizing the properties of existing drugs and, in general the development of various drug-dependent industries, as well as the general health of human, animal and plant communities. These methods provide new drugs at...
متن کاملDrug Design: Structure- and Ligand-Based Approaches
Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are active areas of research in both the academic and commercial realms. This book provides a current snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include x-ray crystallography, nuclear magnetic resonance, fragment-based drug design, free-energy methods, docking a...
متن کاملA Novel Design of Quaternary Inverter Gate Based on GNRFET
This paper presents a novel design of quaternary logic gates using graphene nanoribbon field effect transistors (GNRFETs). GNRFETs are the alternative devices for digital circuit design due to their superior carrier-transport properties and potential for large-scale processing. In addition, Multiple-valued logic (MVL) is a promising alternative to the conventional binary logic design. Sa...
متن کاملModern prodrug design for targeted oral drug delivery.
The molecular information that became available over the past two decades significantly influenced the field of drug design and delivery at large, and the prodrug approach in particular. While the traditional prodrug approach was aimed at altering various physiochemical parameters, e.g., lipophilicity and charge state, the modern approach to prodrug design considers molecular/cellular factors, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutical Chemistry Journal
سال: 2009
ISSN: 0091-150X,1573-9031
DOI: 10.1007/s11094-009-0240-0